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Role of Quinone Metabolites in PAH Carcinogenesis |
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| Authors: | R. G. Harvey T. M. Penning J. Jarabak F.-J. Zhang |
| Affiliation: | 1. Ben May Institute for Cancer Research, University of Chicago , Chicago, Illinois, 60637;2. Department of Pharmacology , University of Pennsylvannia , Philadelphia, PA, 19104;3. Department of Medicine , University of Chicago , Chicago, Illinois, 60637 |
| Abstract: | Evidence concerning the role of dihydrodiol dehydrogenase-catalyzed formation of quinone metabolites in the mechanism in PAH carcinogenesis is reviewed and methods for the synthesis of the adducts formed by reaction of PAH quinone metabolites with DNA are reported. |
| Keywords: | PAH quinone metabolites quinone-DNA adducts dihydrodiol dehydrogenase oxygen radicals oxidative DNA damage. |