辛伐他汀治疗肾移植术后高脂血症患者

目的 研究辛伐他汀对肾移植术后高脂血症患者的疗效。方法 17例肾移植术后患者每日口服辛伐他汀10mg,持续时间1个月。口服辛伐他汀前后患者自肘静脉采血,以标准酶法在自动生化分析仪上测定血浆总胆固醇、甘油三酯浓度,并以特异性荧光偏振免疫法测定环孢素全血药物浓度。结果 17例肾移植术后患者在口服辛伐他汀每日10mg一个月后,血浆总胆固醇水平从8.47±2.18mmol/L显著降至7.59±3.28mmol/L(P<0.05),而甘油三酯水平基本不变,环孢素全血浓度从185.31±39.02ng/ml显著升高至257.33±57.78ng/ml(P<0.01),在口服辛伐他汀的21例患者无1例观察到严重药物不良反应。结论 小剂量的辛伐他汀能有效且比较安全地用于肾移植术后高脂血症患者。

Application of simvastatin in hyperlipidemic patients after renal transplantation1

Aim To study the effect and safety of simvastatin in hyperlipidemic patients after renalt ransplantation.Methods Seventeen hyperlipidemic patients after renalt ransplantation(with to talcholesterol level higher than 6.2 mmol/L)were given simvastatin 10 mg/day for 1 month.The venous blood was collected from an antecubital vein.Plasma lipid and cyclosporine concentration in w hole blood w ere determined before and 1 month after simvastatin administration.Cholesterol (TC)and triglyceride (TG)in plasma w ere determined by standard enzymatical procedures on a Biochem autoanalyzer (Beckman,USA).The blood cyclosporine concentration was determined by specific FPIA method.Results Plasma TC levels w ere decreased markedly from 8.74 ±2.18 mmol/L to 7.59 ±3.28 mmol/L (P<0.05),TG levels were kept unchanged,and the whole blood cyclosporine concentrations w ere increased significantly from 185.31 ±39.02 ng/ml to 257.33 ±57.78 ng /ml (P<0.01)after 1 month of simvastatin administration in 17 recipients.No severe adverse drug reactions were observed.Conclusion Low dose simvastatin can be safely used to treat hyperlipidemic patients after renal transplantation.