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The design of a biochip: a self-assembling molecular-scale memory device
Authors:Robinson  Bruce H; Seeman  Nadrian C
Affiliation:Department of Chemistry, University of Washington Scattle, WA 98195 1Department of Biological Scienes, State University of New York at Albany Albany, NY 12222, USA
Abstract:A design for a biochip memory device based on known materialsand existing principles is presented. The fabrication of thismemory system relies on the self-assembly of the nucleic acidjunction system, which acts as the scaffolding for a molecularwire consisting of polyacetylene-like units. A molecular switchto control current is described which is based on the formationof a charge - transfer complex. A molecular-scale bit is presentedwhich is based on oxidation - reduction potentials of metalatoms or clusters. The readable ‘bit’ which canbe made of these components has a volume of 3x107 Å3 andshould operate at electronic speeds over short distances.
Keywords:biochip/  nucleic acid junctions/  self-assembly/  molecular electronics/  macromolecular design
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