纳米羟基磷灰石/壳聚糖/羧甲基纤维素三元复合骨修复材料的制备和性能研究

用溶液共混法在常温常压下制备了不同比例的纳米羟基磷灰石/壳聚糖/羧甲基纤维素三元复合骨修复材料.用燃烧实验、IR、XRD、SEM及TEM对复合材料的组成结构及形貌进行了分析和观察,并初步研究了其力学性能.结果表明该复合材料中纳米羟基磷灰石均匀分散在壳聚糖和羧甲基纤维素网络结构中,三组分间还产生了一定的相互作用,其形态、尺寸及结构与自然骨类似,且其抗压强度比纳米羟基磷灰石/壳聚糖二元复合材料更高;同时,通过调节各组分比例,可制得不同抗压强度的复合材料.因此,该三元复合材料可望作为一种新型可降解的非承重部位骨修复材料,在生物医学材料的研究中具有重要意义.

Preparation and characterization of nano-hydroxyapatite/chitosan/carboxymethyl cellulosecomposite used for bone repair

Nano-hydroxyapatite/chitosan/carboxymethyl cellulose composites with different weight ratios were prepared by a co-solution method. The properties of the composites were characterized by means of burn-out tests,IR, XRD, SEM, TEM and universal matertial test machine. The results showed that nano-hydroxyapatite dispersed uniformly in the two organism phases, strong chemical interactions were present among the three phases. The composites were similar to bone in morphology, size and structure. Moreover, the compressive strength of the composite was improved compared with nano-hydroxyapatite/chitosan composite, and the composites with different compressive strength can be prepared through altering the ratio of the three compositions. Obviously, the degradable composites prepared here will display a promising prospect for the repair of damaged bone in non load-bearing sites.