人参皂苷活性对冠心病作用的研究进展

人参是在我国应用历史悠久的医食两用养生珍品,具有提高机体免疫力、缓解疲劳、抗衰老等作用。本文主要综述了人参主要的活性成分,人参皂苷的分类及毒性,人参活性成分与炎症反应、氧化应激、细胞凋亡、细胞自噬、线粒体损伤、钙超载的关系,以及人参皂苷在抗动脉粥样硬化、抗心律失常、抗心肌缺血、抑制心室重构方面的作用,以期为利用人参活性成分研发提供理论依据。

Research progress of ginsenosides activity on coronary heart disease

The incidence rate and mortality rate of coronary heart disease account for the first place in cardiovascular disease, which seriously endangers human health. Ginseng has a long history of medical and food dual-purpose health care treasures from China to Southeast Asia. It can improve immunity, relieve fatigue and anti-aging. In recent years, scholars at home and abroad have done a lot of research on the main chemical components, pharmacological effects and clinical application of ginsenosides in coronary heart disease. This paper reviewed the main active components of ginseng, the classification and toxicity of ginsenosides. The relationship between active components of ginseng and inflammation, oxidative stress, apoptosis, autophagy, mitochondrial damage, calcium overload were introduced. The effects of ginsenosides on anti atherosclerosis, anti arrhythmia, anti myocardial ischemia and inhibition of ventricular remodeling were introduced and summarized systematically, in order to provide a theoretical basis for the development of new coronary heart disease drugs using ginseng active ingredients, and to provide scientific basis for further improving the research level of ginsenoside activity and expanding clinical application.