| 盖布瑞尔合成法制备N-(2-羟乙基)-邻苯二甲酰亚胺 |
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| 引用本文： | 李建,刘裕立,李强军,周光红,杨军.盖布瑞尔合成法制备N-(2-羟乙基)-邻苯二甲酰亚胺[J].精细化工中间体,2004,34(4):31-32. |
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| 作者姓名： | 李建 刘裕立 李强军 周光红 杨军 |
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| 作者单位： | 湖南株洲时代新材料科技股份有限公司,湖南,株洲,412007 |
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| 摘 要： | 报道了通过盖布瑞尔合成法制备N (2 羟乙基) 邻苯二甲酰亚胺。以DMF为溶剂,邻苯二甲酰亚胺钾盐与氯乙醇在90℃下反应12h,N (2 羟乙基) 邻苯二甲酰亚胺的收率为86%。讨论了反应温度、反应时间、物料比例以及不同溶剂对反应收率的影响。该方法操作简便,实验条件温和,后处理简便,适合N (2 羟乙基) 邻苯二甲酰亚胺的实验室制备。
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| 关 键 词： | 盖布瑞尔合成法 N-(2-羟乙基)-邻苯二甲酰亚胺 邻苯二甲酰亚胺钾盐 氯乙醇 |
| 文章编号： | 1009-9212(2004)04-0031-02 |
| 修稿时间： | 2004年1月6日 |
Synthesis of N-(2-Hydroxyethyl)phthalimide via Gabriel Method |
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| LI Jian,LIU Yu-li,LI Qiang-jun,ZHOU Guang-hong,YANG Jun.Synthesis of N-(2-Hydroxyethyl)phthalimide via Gabriel Method[J].Fine Chemical Intermediates,2004,34(4):31-32. |
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| Authors: | LI Jian LIU Yu-li LI Qiang-jun ZHOU Guang-hong YANG Jun |
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| Abstract: | The synthesis of N-(2-hydroxyethyl)phthalimide via Gabriel synthesis method was reported. Potassium phthalimide reacted with 2-chloroethanol under 90?℃ or 12?h in DMF solvent, and the isolation yield was about 86%. The influences of reaction temperature,time,ratio of reactants,and solvent on the yields were discussed.The manipulation of this method was simple and it was easy to work up,which had its advantage on preparation of N-(2-hydroxyethyl)phthalimide on labortory scale. |
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| Keywords: | gabriel synthesis N-(2-hydroxyethyl)phthalimide potassium phehalimide 2-chloroethanol |
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