| HPLC法对二种复方氨酚烷胺制剂中对乙酰氨基酚含量测定 |
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| 引用本文： | 苏彦文,张凤荣,苏彦斌.HPLC法对二种复方氨酚烷胺制剂中对乙酰氨基酚含量测定[J].吉林化工学院学报,2012(7):27-30. |
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| 作者姓名： | 苏彦文 张凤荣 苏彦斌 |
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| 作者单位： | [1]吉林化工学院教务处,吉林吉林132022 [2]吉林省食品药品检验所化学研究室,吉林长春130033 [3]吉林化工学院化学与制药工程学院,吉林吉林132022 |
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| 摘 要： | 目的:建立复方氨酚烷胺制剂中对乙酰氨基酚的HPLC含量测定方法.方法:色谱柱Agilent C18柱(150 min×4.6 mm,5μm),V(甲醇)V(0.4%冰醋酸溶液)为75 25为流动相,流速:0.7 mL.min-1,检测波长为249 nm,柱温:30℃.结果对乙酰氨基酚在0.093～0.93μg范围内线性关系良好(r=0.999 99).平均回收率为99.83%,RSD=0.69%(n=9).结论:方法准确可靠,可作为复方氨酚烷胺片剂和胶囊的质量控制方法.
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| 关 键 词： | 复方氨酚烷胺片 复方氨酚烷胺胶囊 对乙酰氨基酚 高效液相色谱法 |
Determination of Acetaminophen in Compound Paracetamol and Amantadine Hydrochloride Capsules and Tablets by HPLC |
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| SU Yan-wen,ZHANG Feng-rong,SU Yan-bin.Determination of Acetaminophen in Compound Paracetamol and Amantadine Hydrochloride Capsules and Tablets by HPLC[J].Journal of Jilin Institute of Chemical Technology,2012(7):27-30. |
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| Authors: | SU Yan-wen ZHANG Feng-rong SU Yan-bin |
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| Affiliation: | 1. Dean＇s Office, Jilin Institute of Chemical Technology,Jilin City 132022, China ;2. Chemistry Research Room, Jilin Institute for Food ＆ Drug Control, Changchun City 130033, China;3. College of Chemistry and Department of Pharmacy Engineering, Jilin Institute of Chemical Technology,Jilin City 132022,China) |
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| Abstract: | Purpose：The method of determining content of acetaminophen in compound paracetamol and amantadine hydrochloride capsules and tablets by HPLC is established.The determination of acetaminophen in compound paracetamol and amantadine hydrochloride capsules and tablets was carried on a column of agilent C18,150×4.6 mm,5 μm,by HLPC.The mobile phase was 7525 of methanol-0.4% glacial acetic acid,the flow rate maintained at 0.7 mlomin-1.The detection wavelength was 249 nm and the column temperature was 30 ℃.The results show that the sample size in determination by HPLC for acetaminophen in compound paracetamol and amantadine hydrochloride capsules and tablets was between 0.093 μg and 0.93 μg,for ideal linearity,r=0.999 9.The average recoveries was 98.83% with the RSD=0.69%,n=9.Conclusion：The method is accurate and reliable for quality control of acetaminophen in compound paracetamol and amantadine hydrochloride capsules and tablets. |
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| Keywords: | compound paracetamol and amantadine hydrochloride capsules compound paracetamol and amantadine hydrochloride tablets acetaminophen HPLC |
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