The effects of vitamin E and selenium intake on oxidative stress and plasma lipids in hamsters fed fish oil |
| |
Authors: | Poirier Johanne Cockell Kevin Hidiroglou Nick Madere Rene Trick Keith Kubow Stan |
| |
Affiliation: | (1) Nutrition Research, Food Directorate, Health Protection Branch of Health Canada, Banting Research Centre, K1A OL2 Ottawa, Ontario, Canada;(2) School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, 21,111 Lakeshore, H9X 3V9 Ste-Anne-de-Bellevue, Québec, Canada |
| |
Abstract: | The aim of the present work was to test the effects of large-dose supplementation of vitamin E (Vit E) and selenium (Se),
either singly or in combination, on fish oil (FO)-induced tissue lipid peroxidation and hyperlipidemia. The supplementation
of Se has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however,
the effects of Se supplementation, either alone or in combination with supplemental Vit E, on FO-induced oxidative stress
and hyperlipidemia have not been studied. Male Syrian hamsters received FO-based diets that contained 14.3 wt% fat and 0.46
wt% cholesterol supplemented with Vit E (129 IU d-α-tocopheryl acetate/kg diet) and/or Se (3.4 ppm as sodium selenate) or that contained basal requirements of both nutrients.
The cardiac tissue of hamsters fed supplemental Se showed increased concentrations of lipid hydroperoxides (LPO) but decreased
oxidized glutathione (GSSG) concentrations. The higher concentrations of LPO in the hearts of Se-supplemented hamsters were
not lowered with concurrent Vit E supplementation. In the liver, Se supplementation was associated with higher Se-dependent
glutathione peroxidase activity and an increase in the GSH/GSSG ratio, whereas a lower hepatic non-Se-dependent glutathione
peroxidase activity was seen with Vit E supplementation. Supplemental intake of Se was associated with lower plasma concentrations
of total cholesterol and low density lipoprotein cholesterol plus very low density lipoprotein cholesterol. In view of the
pro-oxidative effects of Se supplementation on cardiac tissue, a cautionary approach needs to be taken regarding the plasma
lipid-lowering properties of supplemental Se. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|