鹿茸醇提物对小鼠学习记忆功能的影响

目的:研究鹿茸醇提物(AVAE)对小鼠学习记忆能力的影响。方法:156只昆明种雄性小鼠分成空白组(12只小鼠,灌胃生理盐水)、记忆获取阶段组、记忆巩固阶段组和记忆再现阶段组(每组48只小鼠),各阶段组中的高、中、低剂量组每天每只小鼠分别灌胃鹿茸乙醇提取物的干粉量为1kg/(kg·d)、0.5kg/(kg·d)和0.1kg/(kg·d)。灌胃30d,测定各个记忆阶段小鼠跳台实验的潜伏期及错误次数、水迷宫实验的游出时间及错误次数和小鼠大脑内的SOD酶活力及MDA含量。结果:鹿茸醇提物能明显延长各个阶段小鼠跳台实验的潜伏期(P<0.01)并减少错误次数(P<0.01);缩短小鼠水迷宫实验的游出时间及减少错误次数(P<0.01,P<0.05);提高小鼠脑内SOD酶活力(P<0.01,P<0.05);降低小鼠脑内MDA含量(p<0.01,p<0.05)。结论:鹿茸醇提物对小鼠学习记忆障碍有明显的改善作用。

Effect of antler velvet alcohol extracts on improving learning and memory sbilities in mice

Objective:To investigate the effect of antler velvet alcohol extract(AVAE)on learning and memory in mice.Methods:One hundred and fifty-six male Kunming mice were randomized into control group(12 mice,given salty water),memory obtain stage group,memory consolidate stage group and memory reappearance stage group(48 mice in each group),each group had 3 small groups:high dose,mid dose and low dose group,given alcohol extract of antler velvet dry matter on 1kg/(kg·d),0.5kg/(kg·d)and 0.1kg/(kg·d)respectively.After 30d,each stage’s latency and number of errors of jumping platform experiment as well as swimming time and number of errors of water maze were tested,at the same time,the activity of SOD and the content of MDA in mind were evaluated.Results:The AVAE could prolong the latency(P<0.01)of jumping platform experiment on each stage as well as decreasing the number of errors(P<0.01)obviously,and decrease the swimming time and the number of errors(P<0.01,P<0.05)of water maze,then increase the activity of SOD(P<0.01,P<0.05)and decrease the content of MDA in mice brain(P<0.01,P<0.05).Conclusions:The AVAE had the function of improving learning and memory impairment obviously.