| 相转移催化合成N,N-二乙基氨基乙基-3,4-二氯苄基醚 |
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| 引用本文： | 王玉红,宋瑞峰.相转移催化合成N,N-二乙基氨基乙基-3,4-二氯苄基醚[J].精细化工,2002,19(5):304-306. |
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| 作者姓名： | 王玉红 宋瑞峰 |
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| 作者单位： | 1. 苏州科技学院化学系,江苏苏州,215009
2. 南开大学化学系,天津,300071 |
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| 摘 要： | 以二乙氨基乙醇、3,4 二氯氯化苄为原料 ,四丁基溴化铵为相转移催化剂 (PTC) ,氢氧化钠固体为碱 ,苯为溶剂 ,经Williamson醚化反应合成N ,N 二乙基氨基乙基 3,4 二氯苄基醚 ,产率最高可达 84 5 % ,质量分数为 98 7%。最佳合成条件 :n(Et2 NCH2 CH2 OH)∶n(Cl2 ArCH2 Cl)∶n(NaOH)∶n(PTC) =1 2∶1∶2∶0 0 5 ,反应时间为 2h ,反应温度为 6 0℃。产物经过沸点、折光率、红外光谱、氢质子核磁共振谱给予确认
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| 关 键 词： | N N二乙基氨基乙基3 4二氯苄基醚 相转移催化 二乙氨基乙醇 3 4二氯氯化苄 |
| 文章编号： | 1003-5214(2002)05-0304-03 |
Synthesis of N, N-Diethylaminoethyl 3,4-Dichlorobenzyi Ether by Phase Transfer Catalysis |
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| WANG Yu hong ,SONG Rui feng.Synthesis of N, N-Diethylaminoethyl 3,4-Dichlorobenzyi Ether by Phase Transfer Catalysis[J].Fine Chemicals,2002,19(5):304-306. |
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| Authors: | WANG Yu hong SONG Rui feng |
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| Affiliation: | WANG Yu hong 1,SONG Rui feng 2 |
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| Abstract: | N,N Diethylaminoethyl 3,4 dichlorobenzyl ether was synthesized in good yield(84 5%,high purity of 98 7%) by Williamson reaction of diethylaminoethanol and 3,4 dichlorobenzyl chloride using Bu 4NBr as phase transfer catalyst,sodium hydroxide as base and benzene as solvent.The optimized conditions were as follows.Molar ratio of diethylaminoethanol to 3,4 dichlorobenzyl chloride to sodium hydroxide to Bu 4NBr was 1 2∶1∶2∶0 05,reaction time was 2 h and reaction temperature was 60 ℃.Structure of the product was confirmed by boiling point,refractive index,IR and 1H NMR spectrometry. |
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| Keywords: | N N diethylaminoethyl 3 4 dichlorobenzyl ether phase transfer catalysis diethylaminoethanol 3 4 dichlorobenzyl chloride |
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