| 苄青霉素低毒前体苯乙酰基乙醇胺的合成研究 |
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| 引用本文： | 尹汉东,任树梅,刘颖,崔庆新.苄青霉素低毒前体苯乙酰基乙醇胺的合成研究[J].精细化工,1999,16(5):54-56. |
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| 作者姓名： | 尹汉东 任树梅 刘颖 崔庆新 |
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| 作者单位： | 聊城师范学院,化学系,山东,聊城,252059 |
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| 摘 要： | 以苯乙酸乙酯和乙醇胺为原料合成了苄青霉素低毒前体苯乙酰基乙醇胺。最佳合成条件为：ｎ（苯乙酸乙酯）ｎ（乙醇胺）＝ １∶１．０５；催化剂与苯乙酸的质量比为２ ％ ；反应温度为１３０℃；反应时间为３ｈ。产品收率为９７．４ ％ ，纯度≥９８％ 。
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| 关 键 词： | 苯乙酰基乙醇胺 合成 苄青霉素低毒前体 |
| 文章编号： | 1003-5214(1999)05-0054-03 |
Synthesis of A Low Toxic Precurson of Benzylpenicillin- Phenylacetyl Ethanolamine |
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| YIN Han-dong,REN Shu-mei,LIU Ying,CUI Qing-xin.Synthesis of A Low Toxic Precurson of Benzylpenicillin- Phenylacetyl Ethanolamine[J].Fine Chemicals,1999,16(5):54-56. |
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| Authors: | YIN Han-dong REN Shu-mei LIU Ying CUI Qing-xin |
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| Abstract: | The phenylacetyl ethanolamine,a low toxic precurson of benzylpenicillin,was synthesized by using ethyl phenylacetate and colamine as raw materials.The results showed that the best technical conditions were as follows:molar ratio of ethyl phenylacetate to colamine was 1∶1.05,the amount of catalysts was 2%,the reaction temperature was 130℃,the reaction time was 3h,the yield was 97.4%,the purity of the product was no less than 98%. |
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| Keywords: | phenylacetyl ethanolamine synthesis low toxic precurson of benzylpenicillin |
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