The Shortening of MWNT‐SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo |
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| Authors: | Laura Cabana Maxime Bourgognon Julie T‐W Wang Andrea Protti Rebecca Klippstein Rafael T M de Rosales Ajay M Shah Josep Fontcuberta Ester Tobías‐Rossell Jane K Sosabowski Khuloud T Al‐Jamal Gerard Tobias |
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| Affiliation: | 1. Institut de Ciència de Materials de Barcelona (ICMAB‐CSIC), Campus UAB, Bellaterra, Barcelona, Spain;2. Institute of Pharmaceutical Science, King's College London, London, UK;3. Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, UK;4. Cardiovascular Division, James Black Centre, British Heart Foundation Centre of Excellence, King's College London, London, UK;5. Escola Universitària de Ciències de la Salut de Manresa, Universitat de Vic‐Universitat Central de Catalunya, Manresa, Barcelona, Spain;6. Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK |
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| Abstract: | Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle‐like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio‐labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts. |
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| Keywords: | carbon nanotubes dual‐imaging MRI shortening SPECT |
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