| 2-硝基-2-苄基-1,3-丙二醇的合成 |
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| 引用本文： | 陈颖,徐崇福,程耀洲,王昕宇,张杜鹃.2-硝基-2-苄基-1,3-丙二醇的合成[J].江苏石油化工学院学报,2011(2):29-31. |
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| 作者姓名： | 陈颖 徐崇福 程耀洲 王昕宇 张杜鹃 |
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| 作者单位： | 常州大学石油化工学院,江苏常州213164 |
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| 基金项目： | 常州大学科技基金资助（ZMF05020022） |
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| 摘 要： | 2-硝基-2-苄基-1,3-丙二醇是合成药物中间体α-丝氨酸的重要先行体,它由β-硝基苯乙烷与三聚甲醛在碱催化条件下的羟醛缩合反应合成。产物通过重结晶得到无色透明晶体,产率49.01%。对去质子剂、反应物配料比、反应温度以及反应时间进行了优化。产物的结构通过1 H NMR,13CNMR,IR表征。X-Ray单晶衍射分析揭示分子间和分子内氢键的存在。
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| 关 键 词： | 2-硝基-2-苄基-1 3-丙二醇 羟醛缩合反应 α-丝氨酸 单晶X-射线衍射光谱 |
Synthesis of 2-Benzyl-2-Nitropropane-1,3-Diol |
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| CHEN Ying,XU Chong-fu,CHENG Yao-zhou,WANG Xin-yu,ZHANG Du-juan.Synthesis of 2-Benzyl-2-Nitropropane-1,3-Diol[J].Journal of Jiangsu Institute of Petrochemical Technology,2011(2):29-31. |
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| Authors: | CHEN Ying XU Chong-fu CHENG Yao-zhou WANG Xin-yu ZHANG Du-juan |
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| Affiliation: | (School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China) |
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| Abstract: | 2-Benzyl-2-nitropropane-1,3-diol,an important precursor for the synthesis of pharmaceutical intermediate α-serines,was synthesized via Aldol condensation of β-nitrophenylethane and s-trioxane in the presence of a base.A transparent crystalline was obtained after recrystallization with 49.01% yield.The selection of deprotonating agents,ratio of the reactants,reaction temperature and reaction time were optimized.The structure of the product was confirmed by 1H NMR,13CNMR and IR spectroscopy.X-ray crystallography revealed the existence of both inter-and intro-molecular hydrogen bonds. |
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| Keywords: | 2-Benzyl-2-nitropropane-1 3-diol Aldol condensation α-serines X-ray crystallography |
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