Nanocomposite nanofibers of poly(d, l-lactic-co-glycolic acid) and graphene oxide nanosheets |
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Authors: | Ok Ja Yoon Chang Yong Jung Il Yung Sohn Hyung Jin Kim Byungyou Hong Myung S Jhon Nae-Eung Lee |
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Affiliation: | aSchool of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, Kyunggi-do 440-746, Republic of Korea;bSchool of Information and Communication Engineering, Sungkunkwan University (SKKU), Suwon, Kyunggi-do 440-746, Republic of Korea;cDepartment of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA;dSKKU Advanced Institute of Nanotechnology (SAINT) and Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon, Kyunggi-do 440-746, Republic of Korea |
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Abstract: | Significant improvements in the thermomechanical and surface chemical properties of nanocomposite nanofibers of poly(d, l-lactic-co-glycolic acid) (PLGA) were achieved by adding 2-dimensional nanoscale fillers of graphene oxide (GO) nanosheets to PLGA nanofibers. The significant enhancement of storage and loss moduli of the PLGA/GO (2 wt.%.) nanocomposite nanofibers were presumably caused by enhanced chemical bonding between the oxygenated functional groups of the highly dispersible GO nanosheets and the hydroxyl groups of the polymer chains in the PLGA matrix, resulting in strong interfacial interactions between the nanofiller and polymer matrix. Enhanced hydrophilicity of nanocomposite nanofibers caused by embedded GO nanosheets also allowed for good biocompatibility of neuronal cells, resulting in enhanced cell proliferation and viability. Our findings indicate that nanocomposite biopolymer nanofibers embedded with GO nanosheets are attractive candidates for use in biomedical applications such as scaffolds. |
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Keywords: | Graphene oxide nanosheets Nanocomposites Nanofibers Thermomechanical properties |
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