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| 4-氧代-β-紫罗兰酮的合成新方法 | |
| 引用本文： | 钱豪,曹瑞伟,蒋慧巧,崔香美,陈朝辉,张符.4-氧代-β-紫罗兰酮的合成新方法[J].山东化工,2012,41(3):17-19. |
| 作者姓名： | 钱豪 曹瑞伟 蒋慧巧 崔香美 陈朝辉 张符 |
| 作者单位： | 1. 绍兴文理学院,浙江绍兴,312000 2. 浙江医药股份有限公司新昌制药厂,浙江新昌,312500 3. 绍兴英风化工技术有限公司,浙江绍兴,312000 |
| 基金项目： | 2011年浙江省大学生科技创新活动计划 |
| 摘 要： | 研究了以N,N,N-三羟基异腈尿酸(THICA)和Cu(AcAc)2为催化剂,分子氧氧化β-紫罗兰酮,一步反应制备4-氧代-β-紫罗兰酮的工艺;在反应温度为45℃,投料比为n(β-紫罗兰酮):n(THICA):nCu(AcAc)2]=100:10:1,反应5h就能完成,收率为78.2%;并对氧化机理进行了研究。 |
| 关 键 词： | 4-氧代-β-紫罗兰酮 β-紫罗兰酮 THICA Cu(AcAc)2 |
New Method for Synthesis of 4 - Oxo - β- ionone |
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| QIAN Hao,CAO Rui - wei,JIANG Hui - qiao,CUI Xiang - mei,CHEN Chao - hui,ZHANG Fu.New Method for Synthesis of 4 - Oxo - β- ionone[J].Shandong Chemical Industry,2012,41(3):17-19. | |
| Authors: | QIAN Hao CAO Rui - wei JIANG Hui - qiao CUI Xiang - mei CHEN Chao - hui ZHANG Fu |
| Affiliation: | 3 ( 1. Shaoxing University, Shaoxing 312000, China; 2. Xinchang Pharmaceutical Factory, Zhejiang Medicine Co,. Ltd. , Xinchang 312500, China; 3. Shaoxing Yingfeng Chemical＆Technology Co. ,Ltd. , Shaoxing 312000, China) |
| Abstract: | 4- Oxo- β -ionone was synthesized using β -ionone as raw material via oxygenation with moleculeoxygencatalyzedby 1 , 3,5 - trihydroxy - 1 , 3,5 - triazinane - 2,4,6 - trione （ THICA ） and Cu （ AcAc ） 2 . This reaction could be completed at 4 5 ℃ with the molar ratio of β- ionone ： THICA ： Cu （AcAc）2 as 100： 10：1 in 5h to present the yield of 78.2%. And the study of the oxygenation mechanism had been also carried out. |
| Keywords: | 4 - oxo - β - ionone β - ionone THICA Cu (AcAc) 2 |
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