| 心适注射液抗动脉血栓作用机制及其对大鼠血液流变学的研究 |
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| 引用本文： | 徐鹏夫,阚红卫,黄世福,杨士友,陈菡.心适注射液抗动脉血栓作用机制及其对大鼠血液流变学的研究[J].金属学报,2008,13(12):1392-1395. |
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| 作者姓名： | 徐鹏夫 阚红卫 黄世福 杨士友 陈菡 |
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| 作者单位： | 安徽省药物研究所药理室, 安徽省中药研究与开发重点实验室, 合肥 230022, 安徽 |
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| 摘 要： | 目的 研究心适注射液对大鼠血液流变学的作用及其抗动脉血栓作用机制。方法 以胶原蛋白-肾上腺素诱发小鼠体内血栓形成与冰水浴造成血瘀模型, 观察体内、外血栓形成、血小板黏附率及血液流变学的改变。结果 心适注射液各剂量组均明显降低小鼠体内血栓形成以及大鼠血小板黏附率, 改善急性血瘀模型大鼠血液流变学,抑制大鼠血栓形成。结论 心适注射液能改善急性血瘀模型大鼠血液流变学, 有效地对抗动脉血栓的形成。
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| 关 键 词： | 心适注射液 血栓形成 血小板黏附率 血液流变学 |
| 收稿时间： | 2008-06-02 |
| 修稿时间： | 2008-10-29 |
Research of anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheology in rats |
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| XU Peng-fu,KAN Hong-wei,HUANG Shi-fu,YANG Shi-you,CHEN Han.Research of anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheology in rats[J].Acta Metallurgica Sinica,2008,13(12):1392-1395. |
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| Authors: | XU Peng-fu KAN Hong-wei HUANG Shi-fu YANG Shi-you CHEN Han |
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| Affiliation: | Pharmacological Room, Anhui Institute of Materia Medica, the Key Lab of Chinese Traditional Medicine Research and Development, Hefei 230032, Anhui, China |
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| Abstract: | AIM: To study the anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheological in rats.METHODS: The thrombosis model in mice induced by collagen-adrenalin and the blood stasis model in rats induced by icebath were established, then the impacts of Xinshi injection on thrombogenesis in vivo and in vitro, platelet adhesion rate and hemorheology changes were observed.RESULTS: Each dose of Xinshi injection could obviously reduce the thrombosis of mice in vivo and the platelet adhesion rate of rats.It also improved hemorheology of acute blood stasis rats, inhibited thrombosis of model rats.CONCLUSION: Xinshi injection has significant effects on anti-artery thrombosis and hemorheology of acute blood stasis rats. |
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| Keywords: | Xinshi injection thrombogenesis platelet adhesion rate hemorheology |
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