鲨鱼肝再生因子对大鼠慢性肝损伤的治疗作用

目的 探讨鲨鱼肝再生因子(sHRF) 对大鼠慢性肝损伤的治疗作用。方法 CCl₄ 致大鼠慢性肝损伤模型, 给药后取血清及肝组织测定各项肝指标。结果 当用药8 周时, 对CCl₄ 引起的肝损伤大鼠血清中AST 、ALT 活性的升高和羟脯氨酸含量的升高均有抑制作用, 且0.8 、1.6 mg/kg 剂量组的作用差异均有统计学意义。此外, sHRF 能在一定程度上增加白蛋白含量, 并使白蛋白 球蛋白比值有一定程度的升高。肝组织病理切片亦显示sHRF 能减轻CCl₄ 所致大鼠肝细胞脂肪变性及纤维组织增生。结论 sHRF 对CCl₄ 所致大鼠慢性肝损伤有一定的治疗作用。

Therapeutic effects of shark hepatic regenerative factor on chronic liver injury in rats

AIM: The purpose of this study was to evaluate the therapeutic effects of shark hepatic regenerative factor (sHRF) on chronic liver injury in rats.METHODS: Chronic hepatic injury model in rats was induced by Carbon tetrachloride (CCl₄).The activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the content of albumin and total protein in the serum and Hydroxyproline in the liver were measured.RESULTS: Statistics indicated that chronic liver-injured rats with administration for 8 weeks, sHRF could suppress the elevation of ALT, AST in serum andHydroxyproline in liver of liver injury rats induced by CCl₄.There were no significant differences at the dosage of 0.8, 1.6 mg/kg.Moreover, sHRF could increase albumin level and the ratio of albumin and globulin in serum.Hepatic histological findings indicated that sHRF could alleviate liver fibrosis and liver steatosis.CONCLUSION: sHRF had therapeutic effect on chronic liver injury in rats induced by Carbon tetrachloride.