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| 刺五加对急性胰腺炎模型大鼠体内炎性介质的影响 | |
| 引用本文： | 朱健平,李媚芳,陈博,邓修健. 刺五加对急性胰腺炎模型大鼠体内炎性介质的影响[J]. 金属学报, 2008, 13(7): 744-746 |
| 作者姓名： | 朱健平 李媚芳 陈博 邓修健 |
| 作者单位： | 1.广东医学院药理教研室, ;2.广东医学院第一临床学院, ;3.广东医学院生理科学实验室, 东莞 523808, 广东 |
| 摘 要： | 目的:观察刺五加对急性胰腺炎模型大鼠体内炎性介质的影响。方法:经胆胰管逆行注射5%牛磺胆酸钠制备急性胰腺炎模型,术后定时取血,测定血清中肿瘤坏死因子(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)以及淀粉酶(AMY)、脂肪酶(LIP)、磷脂酶A2(PLA2)等的变化。结果:刺五加能降低血清中TNF-α、IL-1、IL-6的水平,降低血清中AMY、LIP、PLA2的活性。结论:刺五加对血清中TNF-α等多种细胞因子和AMY、PLA2的影响,可能是其治疗急性胰腺炎的作用基础。 |
| 关 键 词： | 刺五加 急性胰腺炎 磷脂酶A2 细胞因子 |
| 收稿时间： | 2008-05-15 |
| 修稿时间： | 2008-07-19 |
Effects of acanthopanacis senticosi on inflammatory mediators in rats with acute pancreatitis |
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| ZHU Jian-ping,LI Mei-fang,CHEN Bo,DENG Xiu-jian. Effects of acanthopanacis senticosi on inflammatory mediators in rats with acute pancreatitis[J]. Acta Metallurgica Sinica, 2008, 13(7): 744-746 | |
| Authors: | ZHU Jian-ping LI Mei-fang CHEN Bo DENG Xiu-jian |
| Affiliation: | 1.Department of Pharmacology, ;2.First Clinical College, ;3.Laboratory of Physiology Science, Guangdong Medical College, Dongguan 523808, Guangdong, China |
| Abstract: | AIM: To investigate the effect of acanthopanacis senticosi on the inflammatory mediators in acute pancreatitis(AP) rat models.METHODS: The rat models of AP were induced by intraductal administration of 5% sodium taurocholate, which were killed on time after model induction.The levels of TNF-α, IL-1, IL-6, amylase, lipase and phospholipase A2 in the blood samples were determined.RESULTS: In the acanthopanax senticosus group, the levels of TNF-α, IL-1 and IL-6 were decreased significantly, the activation of serum amylase, lipase, phospholipase A2 were attenuated significantly.CONCLUSION: Acanthopanacis senticosi has protective effect on AP model through cytokine pathways, within which the inhibitory effects on TNF-α, IL-1, IL-6 and phospholipase A2 were the most important mechanism. |
| Keywords: | acanthopanacis senticosi acute pancreatitis phospholipase A2 cytokine |
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