Solubilities of chlormezanone,metaxalone and methocarbamol in supercritical carbon dioxide |
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| Affiliation: | 1. Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan;2. Department of Chemical Engineering, Chinese Culture University, Taipei, Taiwan;1. State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, China;2. École Nationale Supérieure des Industries Chimiques, Université de Lorraine, Laboratoire Réactions et Génie des Procédés—UPR 3349, 1 rue Grandville, BP 20451, Nancy Cedex 9, France;3. Applied Technique College of Southwest Petroleum University, Nanchong 637001, China;1. Department of Food Engineering, State University of Campinas—UNICAMP, 13083-862 Campinas, SP, Brazil;2. Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), State University of Campinas—UNICAMP, 13083-970 Campinas, SP, Brazil;3. Faculty of Pharmaceutical Science, State University of Campinas—UNICAMP, 13081-970 Campinas, SP, Brazil |
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| Abstract: | 
The solubilities of three active pharmaceutical ingredients (APIs) in supercritical carbon dioxide were measured in this study using a semi-flow apparatus. These APIs are chlormezanone (C11H12ClNO3S), metaxalone (C12H15NO3) and methocarbamol (C11H15NO5) that are all used as skeletal muscle relaxants. The solubility data are reported for three isotherms at 308.2, 318.2 and 328.2 K, with the pressure range from 12 to 24 MPa. Most solubility data are within the range of 10−6 to 10−4 mole fraction for each API. The crossover phenomena were observed from the experimental results for all three systems. These solubility data satisfied the thermodynamic consistency tests. They were then correlated using three semi-empirical models. With the optimally fitted binary interaction parameters, satisfactory correlation agreement is presented for each binary mixture. |
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| Keywords: | Solubility Active pharmaceutical ingredient Supercritical carbon dioxide Correlation |
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