OPTIMAL CONTROL OF THE PENICILLIN G FED-BATCH FERMENTATION: AN ANALYSIS OF A MODIFIED UNSTRUCTURED MODEL |
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| Authors: | JAN F. VAN IMPE BART M. NICOLAÏ PETER A. VANROLLEGHEM JAN A. SPRIET JAN A. SPRIET BART DE MOOR |
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| Affiliation: | 1. ESA T—Department of Electrical Engineering , Katholieke Universiteit Leuven , Kardinaal Mercierlaan 94, Leuven, B-3001, Belgium;2. Department of Agricultural Engineering , Katholieke Universiteit Leuven , Kardinaal Mercierlaan 92, Leuven, B 3001, Belgium;3. Department of Agricultural Engineering , Rijksuniversiteit Gent , Coupure Links 653, Cent, B-9000, Belgium;4. Department of Agricultural Engineering , Katholieke Universiteit Leuven;5. ESAT—Department of Electrical Engineering , Katholieke Universiteit Leuven |
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| Abstract: | This paper presents the application of optimal control theory in determining the optimal glucose feed rate profile for the penicillin G fed-batch fermentation, using a modified unstructured mathematical model based on balancing methods. This updated model allows for a smooth transition between maintenance and endogenous metabolism, while all variables take on physically acceptable values under all conditions It is illustrated that the resulting computational algorithm is independent of the exact nature of the metabolism (maintenance or endogenous). In this scheme, the unusual optimization of some free initial states is included. However, as shown by simulations, the nature of the metabolism might be a key factor in concluding whether or not altering the substrate feeding strategy has an important influence on the final amount of product Mathematical and microbial insight leads to the construction of an alternative suboptimal heuristic |
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| Keywords: | Oil-in-water Emulsion Air flotation Film stability |
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