| 富马酸烷·3-PG酯的合成研究 |
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| 引用本文： | 吴跃焕,杨卓如,曾汉维. 富马酸烷·3-PG酯的合成研究[J]. 精细化工, 2002, 19(5): 268-272 |
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| 作者姓名： | 吴跃焕 杨卓如 曾汉维 |
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| 作者单位： | 华南理工大学化工学院,广东广州510641;华南理工大学化工学院,广东广州510641;华南理工大学化工学院,广东广州510641 |
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| 摘 要： | 研究 5种具有良好的抗氧化和抗菌活性的新型化合物———富马酸甲 (乙、丙、丁、戊 )·3 PG酯的合成工艺条件并揭示了其规律。发现富马酸单酯单酰氯与没食子酸丙酯 (PG)的理想反应条件为 :在c(PG) =5 7 0 1mol/L的吡啶溶液中 ,吡啶正常回流温度下 ,分别缓慢滴加富马酸单甲 (乙、丙、丁、戊 )酯单酰氯 ,反应 4 0～ 6 0min ,可获得产率为 75 6 % (78 3%、83 8%、83 3%、76 5 % )的富马酸甲 (乙、丙、丁、戊 )·3 PG酯。随烷基碳链的增长 ,马来酸酐与醇的物质的量比减小 ,反应温度升高和反应时间延长
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| 关 键 词： | 富马酸烷@3-PG酯 富马酸单酯单酰氯 富马酸单酯 |
| 文章编号： | 1003-5214(2002)05-0268-05 |
| 修稿时间： | 2001-10-15 |
Synthesis of Five Fumaric Acid Alkyl 3-PG Esters |
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| WU Yue Huan,YANG Zhuo Ru,ZENG Han Wei. Synthesis of Five Fumaric Acid Alkyl 3-PG Esters[J]. Fine Chemicals, 2002, 19(5): 268-272 |
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| Authors: | WU Yue Huan YANG Zhuo Ru ZENG Han Wei |
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| Abstract: | Technological conditions of synthesizing five fumaric acid alkyl 3-PG esters were studied.The suitable conditions are that n propyl gallate(PG) is dissolved in pyridine with a concentration of 57 01 mol/L and fumaric acid monoalkyl(methyl,ethyl, n propyl, n butyl, n pentyl) monochloride is dropped slowly over 40～60min at 100 ℃.The yields are 75 6%,78 3%,83 8%,83 3% and 76 5% respectively.The molar ratio of maleic anhydride to alcohol should decrease and the reaction temperature and time should increase with elongatoion of the carbon chain of the alkyl group. |
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| Keywords: | fumaric acid alkyl 3-PG ester fumaric acid monoalkyl ester monochloride n monoalkyl fumarate |
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