Diagnosis of sickle-cell disease by DNA analysis in Nigeria |
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Authors: | TA Adewole DK Olukoya A Afonja |
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Affiliation: | Nigerian Institute of Medical Research, Yaba-Lagos, Nigeria. |
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Abstract: | ![]() OBJECTIVE: To compare genotyping of leucocyte DNA by PCR and Dde I with the conventional genotyping of haemoglobin of the same subject. DESIGN: Comparative study. SUBJECTS: 25 adults, 16 males and nine females. MAIN OUTCOME MEASURES: Predictability. RESULTS: In all cases the results were comparable. CONCLUSIONS: The technology can be applied locally to prenatal diagnosis of sickle-cell disease by chorionic sampling and, therefore, improve the management of sickle-cell disease in Nigeria. |
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