In vitro study of lipid peroxidation and free radical scavenging activity of cow urine |
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Authors: | Meeta Lavania Jyotsana Dalal Simrita Cheema Chandra Shekhar Nautiyal Banwari Lal |
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Affiliation: | (1) The Energy and Resources Institute, Lodhi Road, New Delhi, 110003, India;(2) Center for Bioresources and Biotechnology, TERI University, Plot No. 10-Instutional area, Vasant Kunj, New Delhi, 110070, India;(3) National Botanical Research Institute, Rana Pratap Marg, Lucknow, 226001, India; |
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Abstract: | This study represents a comprehensive analysis and scientific validation of our ancient knowledge about the ethnopharmacological
aspects of cow urine by measuring the lipid peroxidation, radical scavenging, and level of reduced glutathione and catalase
activity. Graded doses of cow urine were administered orally to experimentally treated rats. Results of liver and plasma from
experimentally treated rats indicated that cow urine reduced the levels of thiobarbituric acid reactive substance significantly
in all the treatments (P < 0.01). In vitro experiments with the liver of control and experimentally treated rats were also carried out against cumene
hydroperoxide-induced lipid peroxidation. On LCMS analysis, the antioxidant component of cow urine was identified as uric
acid (m/z 169.07). The results demonstrate that the cow urine-mediated induction of antioxidant level controls oxidative damage,
even after minimal processing, and thus is indicative of its potential as a viable substitute of synthetic antioxidants. |
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