多元复合抗性淀粉对高糖高脂模型小鼠代谢调节作用及机制

目的:探讨多元复合抗性淀粉（Resistant starch，RS）对高糖高脂模型小鼠糖脂代谢的改善作用和机制。方法:将小鼠分为六组，分别为正常对照组、高糖高脂模型组、阳性对照组和多元复合RS低、中、高剂量组，评价多元复合RS对高糖高脂小鼠的体质量、总胆固醇（Total cholesterol，TC）、甘油三酯（Triglyceride，TG）、高密度脂蛋白（High-density lipoprotein，HDL-C）、肝糖原及肠道内容物短链脂肪酸（Short chain fatty acids，SCFAs）指标的影响。结果:RS高剂量组与模型对照组相比，多元复合RS组小鼠体质量、血清中的血糖、TC、TG指标分别显著下降9.23%、59.71%、31.22%和36.72%，HDL-C显著上升58.93%；肝糖原含量与多元复合RS的剂量呈正相关，肝糖原含量显著上升207.86%；肠道内乙酸、丙酸、丁酸含量分别显著上升。结论: 多元复合RS可有助于降低高糖高脂模型小鼠的血糖血脂水平，提高肠道内乙酸、丙酸、丁酸的含量。

Metabolic Regulation and Mechanism of Multi-Component Resistant Starch on High-Sugar and High-Fat Model Mice

Objective: To investigate the effect and mechanism of multiple composite resistant starch (RS) on glucose and lipid metabolism in high-sugar and high-fat model mice. Methods: The mice were divided into six groups, namely the normal control group, the high-sugar and high-fat model group, the positive control group and multiple composite RS low dose group, multiple composite RS middle dose group, multiple composite RS high dose group. The effects of multiple complex RS on body mass, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), liver glycogen in high-glycemic and high-fat mice and the influence of short chain fatty acids (SCFAs) in intestinal contents. Results: RS high dose group compared with the mice in the model control group, the body mass, blood glucose, TC, and TG in the serum of mice in the multiple composite RS group were significantly decreased by 9.23%, 59.71%, 31.22%, and 36.72%, respectively, and HDL-C was significantly increased by 58.93%; the content of liver glycogen was positively correlated with the dose of multiple composite RS, and the content of liver glycogen increased significantly by 207.86%. The contents of acetic acid, propionic acid and butyric acid in the intestines increased significantly. Conclusion: The multiple compound RS can reduce the blood sugar level of high-sugar and high-fat model mice, increase the content of acetic acid, propionic acid and butyric acid in the intestine.