Perylenediimide-cored dendrimers and their bioimaging and gene delivery applications |
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| Affiliation: | 1. Department of General and Inorganic Chemistry, Institute of Chemistry, University of Pannonia, P.O. Box 158, 8201 Veszprém, Hungary;2. Division of Physical Chemistry, Ruđer Bošković Institute, P.O.B. 180, HR-10002 Zagreb, Croatia;3. Institute of Physical and Theoretical Chemistry, Graz University of Technology, 8010 Graz, Stremayrgasse 9, Austria, Austria;1. School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China;2. Jinan Academy of Agricultural Sciences, Jinan, 250316, China;1. School of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China;2. Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, Guangdong, PR China;3. Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, Guangzhou 510006, PR China;4. Guangdong Ecological Environment Control Engineering Technology Research Center, Guangzhou 510006, PR China;5. School of Environment, Tsinghua University, Beijing 100084, PR China |
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| Abstract: | In the past few years, perylenediimide-cored (PDI-cored) dendrimers have been successfully prepared and applied in various fields. In this review, we focus on the structural design and synthesis strategies of PDI-cored dendrimers that involve convergent and divergent synthesis approaches. When building the outer shell of PDI-cored dendrimers, first hydrophobic and then hydrophilic macromolecules are introduced. The advantages of water-soluble PDI-cored dendrimers include strong red fluorescence, excellent photostability, low cytotoxicity, high quantum yield, and versatile surface modification. The biological application of water-soluble PDI-cored dendrimers is broad, including fluorescence live-cell imaging, fluorescent labeling, and gene delivery, owing to the rapid development of these materials in the past decade. The challenges and outlooks in this field will also be discussed. |
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| Keywords: | Perylenediimide Dendrimer Convergent approach Divergent approach Bio-application |
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