Decreased serum adiponectin in adolescents and young adults with familial primary hypercholesterolemia |
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Authors: | Lian-Yu?Lin Chiau-Suong?Liau Wei-Shiung?Yang Email author" target="_blank">Ta-Chen?SuEmail author |
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Affiliation: | (1) Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan;(2) Division of Endocrinology & Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;(3) Institute of Industrial Hygiene and Occupational Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan;(4) Departments of Internal Medicine and Occupational Medicine and Industrial Hygiene, National Taiwan University Hospital and Medical College of National Taiwan University, 7, Chung-Shan South Road, 100 Taipei, Taiwan |
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Abstract: | Decreased serum adiponectin is associated with dyslipidemia. However, serum adiponectin status has never before been studied
in patients with familial-related severe primary hypercholesterolemia (FRSPH). The aim of this study is to measure serum adiponectin
level in a group of young patients with FRSPH and determine its correlation with insulin-resistant status. Twenty-three patients
with FRSPH average LDL-cholesterol (LDL-C)=250.8 (190–610) mg/dL] without clinical manifestations of metabolic syndrome as
well as 46 healthy (control) adolescents and young adults (<30 yr old) were included. The serum adiponectin, fasting sugar,
insulin, lipids, systolic and diastolic blood pressure (SBP and DBP), and anthropometrical indices such as body mass index
and waist circumference were obtained. The homeostasis model assessment (HOMA) was calculated to estimate the insulin resistant
status. Compared with healthy controls, patients with FRSPH had a significantly lower mean serum adiponectin level (7.7±1.8
μg/mL vs. 10.1±4.3 μg/mL, P=0.013). After adjustment for HOMA and associated covariates, multiple linear regression analysis showed that patients with
FRSPH are significantly associated with hypoadiponectinemia. Compared with healthy controls, patients with FRSPH had a significantly
lower mean serum adiponectin level (7.7±1.8 μg/mL vs. 10.1±4.3 μg/mL, P=0.013). After adjustment for HOMA and associated covariates, multiple linear regression analysis showed that patients with
FRSPH are significantly associated with hypoadiponectinemia. The serum adiponectin levels are lower in young patients with
FRSPH without clinical manifestations of metabolic syndrome. The mechanism of hypoadiponectinemia in patients with FRSPH is
probably independent of insulin resistance. |
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