环丙沙星对美吡达的药代学和药效学的影响

目的 研究美吡达与环丙沙星联合应用时环丙沙星对美吡达药代动力学及药效学的影响。方法 糖尿病大鼠24 只分为联合用药组(环丙沙星+美吡达)及单独用药组(美吡达),治疗9 d 后分别测定两组美吡达血药浓度并计算药代动力学参数及血糖。结果 两组大鼠美吡达的药代动力学过程均符合一房室模型。且联合用药组美吡达血药浓度显著升高,清除率下降50%(P<0.05),吸收半衰期延长63.7 %(P<0.05),单独应用美吡达治疗后血糖为5.978 mmol·L^-1,联合应用环丙沙星治疗后血糖为5.301 mmol·L^-1;两组降糖效果差异具有显著性。结论 环丙沙星对美吡达的吸收药代动力学有影响,美吡达联合应用环丙沙星降糖效果比单独应用美吡达时强。故同时给药时应注意调整美吡达的用药剂量以保证用药安全。

Effect of ciprofloxacin on pharmacokinetics and pharmacodynamics of glipizide

Aim The effect of ciprofloxacin on the pharmaco-kinetics and the hypoglycemic effect of glipizide was studied.Methods Diabetic rats were given glipizide or glipizide combined with ciprofloxacin for nine days.Serum glipizide samples were assayed and pharmacokinetic parameters were analyzed.Results The concent ration-time curves in diabetic rats were fitted to one compartment model in both glipizide and glipizide combined with ciprofloxacin groups.The concentration of glipizide in glipizide combined with ciprofloxacin grouPwas elevated significantly.The clearance rate of the drug was declined by 50%(P<0.05), t_1/2(Ka)was prolonged by 63.7 % (P<0.05).After treatment of glipizide,or glipizide combined with ciprofloxacin,the blood glucose was 5.978 mmol·L^-1 or 5.301mmol·L^-1respectively. The difference of hypoglycemic effect between glipizide and glipizide combined with ciprofloxacin was significant. Conclusion The ciprofloxacin can affect the absorption of glipizide.The effect of lowering blood glucose of glipizide combined with ciprofloxacin is better than that of glipizide alone.