| 汉防己甲素延缓肾小球硬化机理的实验研究1 |
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| 引用本文： | 董兴刚,卢明,杨海春,曹和欣,朱冬胜,叶传基,徐敏华.汉防己甲素延缓肾小球硬化机理的实验研究1[J].金属学报,2000,5(3):204-206. |
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| 作者姓名： | 董兴刚 卢明 杨海春 曹和欣 朱冬胜 叶传基 徐敏华 |
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| 作者单位： | 上海市第二人民医院肾内科,上海200011;2.复旦大学医学院华山医院肾内科;3.上海中医药大学曙光医院 |
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| 基金项目： | 1上海市跨世纪人才基金资助(№19980409) |
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| 摘 要： | 目的 探讨汉防己甲素对肾小球硬化大鼠肾脏转化生长因子(TGF-β1)基因表达的影响。方法 27只雄性Wistar大鼠随机分为正常对照组、肾小球硬化模型组、汉防己甲素组和氨氯地平组,用单侧肾切除加2次注射阿霉素制备肾小球硬化动物模型,用Northern 印迹杂交,观察肾皮质TGF-β1mRNA表达。结果 汉防己甲素使肾小球硬化大鼠肾皮质TGF-β1mRNA表达较模型组明显下调,肾小球细胞外基质较模型组明显减少。结论 汉防己甲素通过下调TGF-β1表达而减少肾小球ECM沉积,从而延缓肾小球硬化。
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| 关 键 词： | 汉防己 甲素 转化生长因子-β1 肾小球硬化 |
| 收稿时间： | 2000-03-12 |
| 修稿时间： | 2000-05-17 |
Study tetrandrine defer extraceller matrix mechanism |
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| DONG Xing-Gang,LU Ming,YANG Hai-Chun,CAO He-Xing,ZHU Dong-Sheng,YE Chuan-Ji,XU Ming-Hua.Study tetrandrine defer extraceller matrix mechanism[J].Acta Metallurgica Sinica,2000,5(3):204-206. |
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| Authors: | DONG Xing-Gang LU Ming YANG Hai-Chun CAO He-Xing ZHU Dong-Sheng YE Chuan-Ji XU Ming-Hua |
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| Affiliation: | Department of Nephrology, Shanghai Second People's Hospital, Shanghai 200011 |
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| Abstract: | Aim The effect of tetrandrine on TGF-β1 mRNA expression in glomerulosclero sisrat was observed.Methods The rats were randomly divided into four groups, such as the normal control grouP(sham operative rat), glomerulosclerosis model group, tetrandrine grouPand amlodipine grouP.The expression of TGF-β1 mRNA was analyzed by Northern blot hybridization.Results The expressions of TGF-β1 mRNA in two treating groups were much lower than untreated model grouP.There were no difference between these two treating groups.Conclusion Tetrandrine can decrease the expression of TGF-β1 mRNA in glomerulo sclerosis rat induced by unilateral renctomy plus adriamycin. |
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| Keywords: | tetrandrine transforming growth factor-β1 glomerulosclerosis |
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