甘泉6号对大鼠肠系膜微循环的影响

目的 观察甘泉6号对大鼠肠系膜微循环的作用。方法 Wistar 大鼠21只,随机分为3组。1组空白对照;2,3组分别给予甘泉6号1.5g·kg^-1、3.0g·kg^-1,连续灌胃10d,末次给药30min后,经舌静脉注射无菌新鲜羊水2 ml·kg^-1造成微循环障碍模型。结果 对照组注射羊水后,血流速度减慢、血流量减少(P<0.05)。甘泉6 号组注射羊水前后无明显差异(P>0.05)。药物组与对照组比较有统计学意义(P<0.05、P<0.01)。结论 甘泉6 号能预防注射羊水所引起的大鼠肠系膜微循环障碍,同时能增加细胞的耐缺氧能力,改善微循环障碍。

Effect of ganquan 6 on mesenteric microcirculat ion in rats

Aim To observe the effect of Ganquan 6 on mesenteric micro circulation in rat s.Methods 21 Wistar rats were randomly divided into 3 groups (n=7).The first grouPserved as the controled, the other two groups were o rally given ganquan 6 at doses of 1.5 g·kg^-1and 3.0 g·kg^-1for 10 days.30 minutes after the last administration, all the rats were injected 2ml·kg^-1sterile amniotic fluid via lingualis vena.Results In the control group, amniotic fluid injection caused significant decreases in instant blood flow rate and blood flow (P<0.05).In the ganquan 6 treated groups, although amniotic fluid injection failed to cause significant changes in microcirculation, the blood flow rate and blood flow had significant differences from those in the control group(P<0.05,P<0.01).Conclusion Ganquan 6 can improve the microcirculation in rats with microcirculatory disturbance caused by decreasing blood flow rate and blood flow and strengthen anoxia-tolerance of cells.