| 尿素包合法富集分离花生四烯酸的工艺研究 |
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| 引用本文： | 李学坤,夏畅斌,张昆,施海峰,黄和.尿素包合法富集分离花生四烯酸的工艺研究[J].云南化工,2006,33(2):8-11,31. |
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| 作者姓名： | 李学坤 夏畅斌 张昆 施海峰 黄和 |
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| 作者单位： | 1. 湖南科技大学,化学化工学院,湖南,湘潭,411201
2. 南京工业大学,制药与生命科学学院,江苏,南京,210009 |
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| 基金项目： | 江苏省自然科学基金;江苏省博士后科学基金 |
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| 摘 要： | 为提高尿素包合法富集花生四烯酸(AA)效率,研究了降温速度、甲醇用量、尿酯比及结晶温度对花生四烯酸(AA)晶体大小、收率及纯度的影响。结果表明,当结晶温度为-7℃,降温速度为10℃/h,m(脂肪酸甲酯)∶m(尿素):v(甲醇)为1 g∶2 g∶20 mL时,AA生成大颗粒晶体。AA的质量分数w(AA)=87.0%,收率为88.7%。杂质主要为亚麻酸(w=9.21%)。产品总不饱和脂肪酸质量分数大于99%。
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| 关 键 词： | 花生四烯酸 尿素包合 富集 降温速度 结晶 |
| 文章编号： | 1004-275X（2006）02-0008-04 |
| 收稿时间： | 2006-01-12 |
| 修稿时间： | 2006-01-12 |
Purification of Arachidonic Acid by Urea Inclusion |
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| LI Xue-kun,Xia Chang-bin,ZHANG Kun,SHI Hai-feng,HUANG He.Purification of Arachidonic Acid by Urea Inclusion[J].Yunnan Chemical Technology,2006,33(2):8-11,31. |
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| Authors: | LI Xue-kun Xia Chang-bin ZHANG Kun SHI Hai-feng HUANG He |
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| Affiliation: | 1.School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiantan 41120l, China; 2. School of Pharmacy and Life Science, Nanjing University of Technology, Nanjing 210009, China |
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| Abstract: | Purification of arachidonic acid from fungi lipids by urea inclusion was studied,and effect of crystallization temperature,cool speed,ratio of urea to fatty and volume of methanol on the yield and purity of arachidonic acid was investigated.Result showed that crystallization at-7 ℃,cool speed at 10℃/h and ratio of urea to fatty acid to methanol as 1g: 2g: 20mL were the optimal condition.The content of polyunsaturated fatty acids in the obtained product was 99%,with 87.2% of arachidonic acid and the yield of 88.7%. |
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| Keywords: | araehidonic acid urea inclusion enrichment cool speed crystallization |
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