天然白地霉菌株发酵产品的毒理安全性评价

研究产香白地霉菌株发酵产品的食用安全性。采用小鼠急性毒性试验、骨髓细胞微核试验、小鼠精子畸形试验和30d喂养试验进行毒理学研究。急性毒性试验表明，白地霉发酵产品的小鼠LD50〉10．0g／kg体重，说明该受试物属于无毒级物质。骨髓细胞微核试验和小鼠精子畸形试验的结果为阴性，未显示出致突变性。30d喂养试验中各实验组（2．5、5．0、10．0g／kg体重）小白鼠生发育良好，体重、食物利用率，以及血常规、血液生化指标与对照组之间无显著差异，小白鼠组织解剖检查均未见病变，产香白地霉菌株发酵产品具有较好的饮用安全性，可作为饮料供消费者饮用。

Toxicological assessment of fermented product by Geotrichum candidum

Object: The paper assessed the edible-safety of the fermented product of Geotrichum candidum. The toxicological safety properties were examined by a series experiments of acute toxicity, bone marrow cell micronucleus, sperm shape aberration and 30 d feeding test. The results of the acute toxicity test showed that the LD50 of the fermented product of Geotrichum candidum was more than 10. 0g/kg bw, which fell into the scope of non-toxicity. The results of negative test groups were observed in the genetic toxicity test of bone marrow cell micronucleus and sperm shape aberration test. Abnormal phenomena had not been found in 30 days feeding test under the experimental dosage range of 2. 5, 5. 0, 10. 0g/kg bw. Conclusion: The fermented product of Geotrichum candidum has a good edible-safety property for consumers drinking.