A novel phorbol ester from Excoecaria agallocha |
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| Authors: | KL Erickson JA Beutler JH Cardellina JB McMahon DJ Newman MR Boyd |
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| Affiliation: | Laboratory of Drug Discovery Research and Development, National Cancer Institute, NCI-FCRDC, Maryland 21702-1201, USA. |
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| Abstract: | ![]()
The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was determined by spectral means. Compound 1 was also a potent displacer of [3H]-phorbol dibutyrate from rat brain membranes. |
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