顺铂与环磷酰胺联合应用剂量优化的实验研究

目的: 观察低剂量顺铂(DDP)和环磷酰胺(DTX)联合用药治疗恶性肿瘤疗效及其对免疫器官的毒性。方法: 采用小鼠肉瘤S180进行体内实验,观察两药单独及联合使用对小鼠S180 及胸腺和脾脏的影响。结果: DDP组和不同剂量的DTX 配伍应用与DDP组相比抑瘤率分别提高13.6%~29.6%,与相应剂量DTX 组相比抑瘤率分别提高33.5 % ~34.3 %,其中DDP+DTX 0.75 +7.5mg·kg^-1组与DDP及相应剂量DTX 组相比较有显著意义(P<0.01~0.001);DDP组及两药联合应用各剂量组使小鼠胸腺指数和脾指数明显低于对照组。结论: 低剂量DDP与DTX 联合使用加强了对肿瘤生长的抑制作用,与DDP组相比,联合应用引起的免疫器官的萎缩与DDP组无差别。

Does selection of combination treatment of cisplatin and cyclophosphamide

AIM: To investigate the anticancer effects and toxicity of cisplatin and cyclophosphamide used alone and in combination in treatment of the mice models with sarcoma 180 (S₁₈₀).METHODS: The anticancer effects and toxicity were evaluated by the inhibition rate, the indexes of thymus and spleen.The growth of tumor was observed by mice models of transplant tumor.RESULTS: The inhibition rate of co-treatment of cisplatin(5.0mg·kg^-1) and cyclophosphamide (7.5 mg·kg^-1) increased 13.6 % -29.6 %, and 33.5 % -34.3 % in comparison with cisplatin and cyclophosphamide, respectively.The inhibition rate in the groups of co-treated was higher than that of in the group of cisplatin and cyclophosphoamide(7.5mg·kg^-1) (P<0.01-0.001).CONCLUSION: Co-treatment of cisplatin in lower dose with cyclophosphamide shows a synergetic anticancer effect in mice models.