| 新型KATP开放剂埃他卡林对氟哌啶醇诱导的大鼠帕金森样症状的影响 |
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| 引用本文： | 龙燕,杨勇,丁建花,胡刚. 新型KATP开放剂埃他卡林对氟哌啶醇诱导的大鼠帕金森样症状的影响[J]. 金属学报, 2004, 9(4): 378-381 |
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| 作者姓名： | 龙燕 杨勇 丁建花 胡刚 |
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| 作者单位： | 南京医科大学药理学与神经生物学系, 南京210029, 江苏 |
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| 基金项目： | 国家创新药物基础研究重大项目(№969010101);国家自然科学基金资助项目(№39970846) |
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| 摘 要： | 目的:研究ATP 敏感性钾通道(ATP-sensitive potassium channels, KATP) 开放剂埃他卡林(Iptakalim, Ipt) 对由氟哌啶醇(haloperidol) 诱导产生的大鼠帕金森样症状的影响。方法:应用氟哌啶醇诱导大鼠帕金森样症状, 以左旋多巴(levodopa, L-DOPA) 为阳性对照, 观察不同剂量Ipt 对大鼠运动潜伏时间、行走时间以及直立和梳洗次数的影响。结果:Ipt 能显著改善氟哌啶醇引起的大鼠自发性活动减少;能缓解氟哌啶醇引起的大鼠全身僵硬, 并且随剂量的增加,Ipt 的作用逐渐增强。结论:KATP 通道开放剂Ipt 能够改善氟哌啶醇引起的大鼠帕金森样症状, 是一个极富治疗潜力的先导化合物。
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| 关 键 词： | ATP 敏感性钾通道 开放剂 埃他卡林 氟哌啶醇 帕金森样症状 |
| 收稿时间： | 2004-01-08 |
| 修稿时间： | 2004-02-27 |
Effects of new ATP-sensitive potassium channel pener iptakalim on Parkinsonian symptoms induced by haloperidol in rats |
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| LONG Yan,YANG Yong,DING Jian-Hua,HU Gang. Effects of new ATP-sensitive potassium channel pener iptakalim on Parkinsonian symptoms induced by haloperidol in rats[J]. Acta Metallurgica Sinica, 2004, 9(4): 378-381 |
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| Authors: | LONG Yan YANG Yong DING Jian-Hua HU Gang |
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| Affiliation: | Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing 210029, Jiangsu, China |
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| Abstract: | AIM: To investigate the effects of the new KATP channel opener, Iptakalim (Ipt), on the Parkinsonian symptoms induced by haloperidol in rats. METHODS: Using L-DOPA as the positive drug, the influences of Ipt on latency time, walking time, rearing and grooming of the parkinsonian-like rats induced by haloperidol were observed.RESULTS: Ipt ameliorated hypolocomotion and assuaged catalepsy induced by haloperidol in rats. Moreover, the effects of Ipt (0.5 mg·kg-1) were better than those of L-DOPA (100 mg·kg-1).CONCLUSION: Opening of KATP channels may play a key role in improving Parkinsonian symptoms induced by haloperidol in rats. |
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| Keywords: | ATP-sensitive potassium channel opener iptakalim haloperidol parkinsonian symptoms |
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