Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Attenuates TNBS-Induced Experimental Colitis |
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| Authors: | Marta Szandruk-Bender,Benita Wiatrak,Stanisł aw Dzimira,Anna Merwid-Lą d,Ł ukasz Szczukowski,Piotr Ś wią tek,Adam Szelą g |
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| Affiliation: | 1.Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland;2.Department of Pathology, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland;3.Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland |
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| Abstract: | ![]()
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| Keywords: | experimental colitis, trinitrobenzenesulfonic acid, inflammatory bowel disease, pyrrolo[3,4-d]pyridazinone, inflammatory mediators, Th17/Treg axis, RORγ t, Foxp3, IL-6, IL-23 |
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