| ~(18)F标记正电子分子探针在肿瘤受体显像的应用 |
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| 引用本文： | 贾丽娜,张岚.~(18)F标记正电子分子探针在肿瘤受体显像的应用[J].同位素,2015,28(2):121-128. |
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| 作者姓名： | 贾丽娜 张岚 |
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| 作者单位： | 中国科学院上海应用物理研究所放射化学与工程技术部;中国科学院钍基熔盐堆核能系统卓越创新中心;中国科学院核辐射与核能技术重点实验室 |
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| 基金项目： | 中国科学院先导科技专项(XDA02030000) |
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| 摘 要： | 肿瘤受体显像具有高亲和性、高特异性、高选择性及良好的药代动力学特性,在肿瘤的诊断和分期中具有重要作用。本文根据不同的肿瘤受体,对生长抑素(SST)受体、血管活性肠肽(VIP)受体、肿瘤生长因子受体、类固醇激素(SH)受体类肿瘤受体显像剂的18F标记的正电子分子探针进行了综述。
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| 关 键 词： | 肿瘤受体 正电子分子探针 18F标记 分子影像 |
Application of 18F-Labeling Positron Molecular Probes in Tumor Receptor Imaging |
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| JIA Li-na;ZHANG Lan.Application of 18F-Labeling Positron Molecular Probes in Tumor Receptor Imaging[J].Isotopes,2015,28(2):121-128. |
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| Authors: | JIA Li-na;ZHANG Lan |
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| Affiliation: | 1.Department of Radiochemistry and Engineering, Shanghai Institute of Applied Physics, China Academy of Sciences, Shanghai 201800, China; 2.CAS center for excellence TMSR energy system, Shanghai 201800, China; 3.Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, China Academy of Sciences, Shanghai 201800, China |
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| Abstract: | Tumor receptor imaging characterized by high affinity, high specificity, high selectivity and favorable pharmacokinetic properties, plays a significant role in the diagnosis and staging of tumor. The research progress of 18F labeling positron molecular probes for tumor receptor imaging were reviewed according to tumor receptors which included somatostatin (SST) receptor, vasoactive intestinal polypeptide (VIP) receptor, tumor growth factor receptors, and steroid hormone (SH) receptors. |
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| Keywords: | tumor receptor positron molecular probe 18F labeling molecular imaging |
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