| β-酮酸酯类化合物与丁烯酮的Micheal加成反应研究 |
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| 引用本文： | 李晨辉,鲍莹,张辉,刘建宇,许永男.β-酮酸酯类化合物与丁烯酮的Micheal加成反应研究[J].辽宁化工,2014(10):1236-1237. |
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| 作者姓名： | 李晨辉 鲍莹 张辉 刘建宇 许永男 |
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| 作者单位： | 沈阳药科大学教育部基于靶点的药物设计与研究重点实验室; |
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| 摘 要： | 2-氧代环戊烷甲酸甲酯或2-氧代环己烷甲酸甲酯与短链α,β-不饱和羰基化合物丁烯酮在六水合三氯化铁催化、无溶剂条件下进行Michael加成反应,能有效避免副反应的发生。该方法也可应用于其他β-酮酸酯类化合物,反应简便易行,收率高。所得到化合物结构均经1H-NMR和MS谱确证。
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| 关 键 词： | β-酮酸酯 Micheal加成反应 α β-不饱和酮 |
Michael Addition Reaction of β-Keto Esters and Methyl Vinyl Ketone |
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| Affiliation: | LI Chen-hui;BAO Ying;ZHANG Hui;LIU Jian-yu;XV Yong-nan;Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University; |
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| Abstract: | Using ferric chloride hexahydrate as the catalyst, the Michael addition reaction between esters of 2-oxocyclopentanecarboxylic acid and short chain α,β-unsaturated carbonyl compound under solvent free conditions was carried out, the side reactions were effectively avoided. And the product was characterized by 1H-NMR and mass spectrometry. The method has simple operation and high yield. |
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| Keywords: | β-keto esters Michael addition reaction short chain α β-unsaturated carbonyl compounds |
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