载抗菌肽与海藻酸盐的微纳结构钛的制备（研究生论坛）

为了获得同时具有良好骨相容性与抗感染能力的钛植入材料，通过酸蚀与阳极氧化技术构了建具有微孔/纳米管结构的钛底材，并使用层层组装的方式于其上装载牛乳铁蛋白肽与藻酸钠。对材料使用扫描电镜、X射线光电子能谱分析、接触角测试进行表征，并使用紫外分光光度计检测载药量。通过仿生矿化实验，分析了材料的生物矿化能力。实验结果表明，在较大电压下制得的具有较大管径纳米管结构的样品能装载更多药物。各组材料均具有良好的亲水性。同时载药样品具有促进生物矿化的性能。

Construction of micro/nano structural titanium loading alginate and antimicrobial peptide

In order to gain both bioactivity and antimicrobial ability, titanium with microporous/nanotubes structure on its surface was fabricated by acid etching and subsequently anodization at different voltages and bovine lactoferricin and alginates were loaded through layer by layer assembly. Samples were analyzed by scanning electron microscopy, X-ray photoelectron spectroscopy, contact angle test and the loaded drug amount was determined with ultraviolet spectrophotometer. Then the biomineralization ability was studied by biomimetic mineralization experiments. The results indicated that samples with nanotubes of bigger diameter carried more drugs. The materials are of good hydrophilicity. Also drug-loaded samples induced the mineralization.