| 苯噻菌胺的合成 |
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| 引用本文： | 杨芳,廖道华,师文娟,刘少春,杜梦.苯噻菌胺的合成[J].农药,2010,49(3). |
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| 作者姓名： | 杨芳 廖道华 师文娟 刘少春 杜梦 |
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| 作者单位： | 华东理工大学药学院,上海,200237 |
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| 摘 要： | 以2-氨基-5-氟硫酚为起始原料,经N-羰基-D-丙氨酸酐脱羧环合制得(R)-1-(6-氟-苯并噻唑-2-)乙胺(1);L-缬氨酸采取分步反应,经过酰胺化,羧基活化后与(1)反应,合成目标产物苯噻菌胺.反应总收率56.7%,含量96.6%(HPLC),产物经1H NMR、MS进行了表征.
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| 关 键 词： | 杀菌剂 苯噻菌胺 2-氨基-5-氟硫酚 合成 |
Synthesis of Benthivalicarb-isopropyl |
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| YANG Fang,LIAO Dao-hua,SHI Wen-juan,LIU Shao-chun,DU Meng.Synthesis of Benthivalicarb-isopropyl[J].Pesticides,2010,49(3). |
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| Authors: | YANG Fang LIAO Dao-hua SHI Wen-juan LIU Shao-chun DU Meng |
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| Affiliation: | Pharmacy School/a>;East China University of Science and Technology/a>;Shanghai 200237/a>;China |
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| Abstract: | Benthivalicarb-isopropyl was synthesized from 2-amino-5-fluorobenz-enethiol via decarboxylation,cyclization,amidation and carboxy activation.The total yield of benthivalicarb-isopropyl was 56.7%,and the content was 96.6%.The products were determined by 1H NMR and MS. |
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| Keywords: | fungicide benthivalicarb-isopropyl 2-amino-5-fluorobenzenethiol synthesis |
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