钛基表面TiO_2-HA生物陶瓷膜层的血液相容性研究

采用微弧氧化法及微弧氧化-水热法对纯钛进行改性,制备了TiO_2与TiO_2-HA生物陶瓷膜层,通过溶血率实验、动态凝血时间实验和血小板黏附实验等方面评价其血液相容性。结果表明:各试样的溶血率都远小于5%,均符合医用材料的溶血率要求,不会产生溶血作用。与钛基TiO_2生物陶瓷膜层和钛基材相比,钛基TiO_2-HA生物陶瓷膜层的溶血率更低,动态凝血时间曲线变化更为缓慢,黏附的血小板更少,且变形程度更轻,具有更好的抑制血小板的聚集与变形的性能,血液相容性更优。

Blood Compatibility of TiO2-HA Bioceramic Coating on Titanium

Modified titanium materials, including TiO₂ and TiO₂-HA bioceramic coatings, were prepared by micro-arc oxidation and micro-arc oxidation-hydro-thermal methods. Determination of the hemocompatibility of the coatings through a hemolysis experiment, dynamic clotting time test, and platelet adhesion experiment was also performed. The results demonstrated that: Hemolysis rates of all samples were less than 5%, no hemolysis was observed. Compared with titanium and TiO₂ bioceramic coating of titanium, TiO₂-HA bioceramic coating of titanium exhibited lower hemolysis rate, slower change in dynamic clotting time and less platelet adherence. The proposed TiO₂-HA bioceramic coating further showed a lower degree of deformation, better inhibition of platelet aggregation and deformation, and excellent hemocompatibility.