| 不同方法测定生物制品中硫柳汞含量的比较 |
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| 引用本文： | 何鹏,邱少辉,郭玉芬,饶洪冲,朱征宇,金于兰,秦洁,潘海龙,洪小栩,胡忠玉,梁争论.不同方法测定生物制品中硫柳汞含量的比较[J].粉末涂料与涂装,2010,23(2). |
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| 作者姓名： | 何鹏 邱少辉 郭玉芬 饶洪冲 朱征宇 金于兰 秦洁 潘海龙 洪小栩 胡忠玉 梁争论 |
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| 作者单位： | 何鹏,邱少辉,胡忠玉,梁争论(中国药品生物制品检定所病毒二室,北京,100050);郭玉芬(北京天坛生物制品股份有限公司质检部,北京,100024);饶洪冲,朱征宇(深圳康泰生物制品有限公司质检部,广东深圳,518057);金于兰,秦洁(上海生物制品研究所质检部,上海,200052);潘海龙(成都生物制品研究所质检部,成都,610023);洪小栩(国家药典委员会生物制品处,北京,100061) |
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| 摘 要： | 目的比较原子吸收分光光度法(简称仪器法)与滴定法测定生物制品中硫柳汞含量的精密性和准确性,为仪器法列入《中国药典》(2010版)提供依据。方法由不同实验室分别采用仪器法与滴定法测定不同硫柳汞含量的样品,并进行精密性和准确性比较。结果不同实验室在测定硫柳汞含量为65.8、25.0及1.5μg/ml的样品时,仪器法的变异系数均小于滴定法,回收率较滴定法更接近100%;在测定硫柳汞含量为100μg/ml的样品时,两种方法回收率均不理想,但仪器法优于滴定法。结论仪器法测定生物制品中硫柳汞含量的精密性和准确性均优于滴定法,但仍需进一步完善。
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| 关 键 词： | 硫柳汞 滴定法 原子吸收分光光度法 |
Determination of Thiomersal Content in Biological Products by Various Methods |
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| HE Peng,QIU Shao-hui,GUO Yu-fen,et al.Determination of Thiomersal Content in Biological Products by Various Methods[J].Chinese Journal of Biologicals,2010,23(2). |
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| Authors: | HE Peng QIU Shao-hui GUO Yu-fen |
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| Affiliation: | HE Peng,QIU Shao-hui,GUO Yu-fen,et al(National Institute for the Control of Pharmaceutical , Biological Products,Beijing 100050,China) |
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| Abstract: | Objective To compare the precision and accuracy of atomic absorption spectrophotometry and titration method in determination of thiomersal content in biological products,and provide a basis for inclusion of atomic absorption spectrophotometry into Chinese Pharmacopoeia(2010 edition).Methods The test samples with different thiomersal contents were determined by the two methods in different laboratories,and the precision and accuracy were compared.Results The coefficients of variation of determination results... |
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| Keywords: | Thiomersal Titration method Atomic absorption spectrophotometry |
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