乳脂肪球膜的特性、开发及在模拟母乳脂肪球结构中的应用

乳脂肪球膜（milk fat globule membrane，MFGM）是包裹在天然乳脂肪球外部的3 层膜状结构，然而牛乳基和大豆基婴儿配方奶粉缺少MFGM，脂肪球结构与母乳存在较大差异，因此添加外源MFGM以及制备与母乳脂肪球结构接近的婴儿配方奶粉成为了近期的研究焦点。本文综述了MFGM的相关特性和生产开发途径，以及牛乳MFGM在仿母乳脂肪球结构乳液和婴儿配方奶粉中的应用。体外模拟婴儿胃肠道消化实验以及啮齿动物体内实验结果表明，仿母乳脂肪球结构乳液和婴儿配方奶粉能够促进婴儿脂肪消化并且改善脂质代谢过程。

Characteristics and Development of Milk Fat Globule Membrane and Its Applications in Simulating Human Milk Fat Globule Structure

The milk fat globule membrane (MFGM) is a three-layer membrane structure that surrounds milk fat globules. The structure of fat globules in cow milk-based and soy-based infant formulas, lacking MFGM, is quite different from that in human milk. Therefore, addition of exogenous MFGM and preparation of infant formulas with fat globule structure similar to that in human milk have become the focus of recent research. In this article, we review the characteristics and development of MFGM, as well as the application of bovine MFGM in emulsions and infant formulas mimicking the human milk fat globule structure. Simulated in vitro infant gastrointestinal digestion and rodent studies in vivo have demonstrated that the mimic structure of human milk fat globule in emulsions and infant formulas can promote fat digestion and improve lipid metabolism in infants.