Syntheses and antitumor activities of polymers containing 2-acrylamido-2-methyl-1-propanesulfonic acid or 5-fluorouracil |
| |
Authors: | Sun Mi Lee Seong Suk Ju Hae Young Chung Chang Sik Ha Won Jei Cho |
| |
Affiliation: | (1) Department of Polymer Science & Engineering, Pusan National University, Pusan 609-735, Korea Tel.: +82-51-510-2403, Fax: +82-51-513-7720, KR;(2) Department of Pharmacy, Pusan National University, Pusan 609-735, Korea, KR |
| |
Abstract: | Summary
The polymers containing 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPA) were prepared by radical polymerizations. The
polymers were identified by FT-IR, 1H-, and 13C-NMR spectroscopies. The contents of AMPA unit in poly(AMPA-co-MAH), terpoly(AMPA-MAH-FUR), and poly(AMPA-co-EETFU) were 67, 73 and 49 mol %, respectively. The number average molecular weights of the polymers determined by GPC were
in range from 5,600 to 9,200. The IC50 values of the synthesized polymers against cancer cell lines were in the range of 0.02 to 127. The in vivo antitumor activities of polymers against Balb/C mice bearing the sarcoma 180 tumor cells were greater than those of 5-FU.
Received: 6 September 2000/Revised version: 12 March 2001/Accepted: 22 March 2001 |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|