| Bioeompatibility of Compounds of Extracellular Matrix and Thermally Reversible Hydrogel |
| |
| 作者姓名： | YAO Yi YANG Sixing ZHANG Ci YU Xiaoxiang |
| |
| 作者单位： | [1]Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China [2]Department of Urology, 303rd Hospital of PLA, Nanning 530021, China |
| |
| 基金项目： | Funded by the Natural Science Foundation of Hubei Province （No.2003ABA187） and by Hubei Education Bureau （No.2003X123） |
| |
| 摘 要： | A new scaffold material composed of extracellular matrix （ECM） and thermal sensitive hydrogel （HG）, and evaluated its biocompatibility were investigated. We cultured bladder smooth muscle cells with this compound material, and then observed with phase contrast microscopy and scanning electron microscope （SEM） to assess the cell growth and morphology. The cell adhesion and proliferation were detected with MTT assay and cell count. Results show the ECM/HG compounds appeared as a net-like and red-stained construction with enough meshes and without any cellular fragments. 6 h after implantation, cells were observed adhere on the compounds and extend spurious along the fibers 12 h later. Under SEM even some ECM was observed to be secreted. MTT assay shows there was obvious statistic difference among 3 groups （P〈0.05）. ECM/HG compound materials show a good biocompatibility, which confirms that it would be an ideal tissue engineering scaffolds.
|
| 关 键 词： | 生物材料 生物适应性 热可逆水凝胶 复合材料 |
| 修稿时间： | 2006-03-18 |
Bioeompatibility of Compounds of Extracellular Matrix and Thermally Reversible Hydrogel |
| |
| YAO Yi YANG Sixing ZHANG Ci YU Xiaoxiang.Bioeompatibility of Compounds of Extracellular Matrix and Thermally Reversible Hydrogel[J].Journal of Wuhan University of Technology. Materials Science Edition,2007,22(3):439-442. |
| |
| Abstract: | |
| |
| Keywords: | extracellular matrix hydrogel compounds materials biocompatibility |
| 本文献已被 维普 等数据库收录！ |
