Development and Validation of a Drug Release Rate Method for a Water Soluble Drug in a Liposome Preparation |
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Authors: | Sriram Vemuri C T Rhodes |
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Affiliation: |
a Department of Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Kingston, RI |
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Abstract: | An in vitro method was developed to determine the rate of drug release from a liposome preparation. Three batches of liposomes containing orciprenaline sulphate were evaluated for release of drug over a 24 hour period in an end-over-end tumbler device. Intra and inter day precision studies indicate good reproducibility for this test method. This method is easy to use in drug development and quality control laboratories to evaluate drug release from liposome formulations. |
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