脑卒中后抑郁患者脑电信号长时程相关性分析

为调查单侧半球损伤的脑卒中后抑郁患者脑电宽频振荡的长时程相关特性,利用去趋势波动分析这一可量化反映脑电信号长时程相关性的方法,研究了18例脑卒中后抑郁患者(8例左半球受损,10例右半球受损),22例脑卒中后无抑郁患者(12例左半球受损,10例右半球受损)宽频带(0.6~46 Hz)脑电信号在0.2~3 s时间尺度下的长时程相关特性。研究发现,虽然左半球受损抑郁患者较右半球受损患者抑郁情况更为严重,但是仅有右半球受损抑郁患者脑电信号长时程相关性在抑郁相关的脑区有显著性减弱,这暗示了不同半球受损脑卒中患者PSD发生的机制不同,PSD与脑卒中受损部位间存在着复杂的关系。

Long range temporal correlation analysis of EEG oscillation in poststroke depression patients

In order to investigate the long range temporal correlations (LRTC) of broadband EEG oscillation in poststroke depression (PSD) patients with unilateral hemispheric injury, Broadband EEG (0.6~46 Hz) of 18 poststroke depression patients (8 left hemispheric lesion and 10 right hemispheric lesion) and 22 poststroke non depression patients (12 left hemispheric lesion and 10 right hemispheric lesion) in the time range of 0.2~3 s. The results show that, although the depressive symptoms is more severe in depressed patients of left lesion than right lesion, significantly decreased LRTC in depressive related brain regions only found in PSD patients with right hemispheric lesion. The results that the pathophysiology of PSD in different hemispheric damage different and support the notion that the association between poststroke depression and lesion location is complex.