强碱性阴离子交换树脂用于90YCl3溶液金属杂质的纯化

从⁹⁰Sr/⁹⁰Y放射性衰变平衡体系中分离获得的90Y溶液具有无载体、金属杂质含量高等特点，需要进一步纯化才能应用于⁹⁰Y放射性药物的制备。本工作研究了AE4强碱性阴离子交换树脂在盐酸溶液中对Y³⁺、Fe³⁺、Al³⁺、Zn²⁺、Mg²⁺的吸附性能。结果表明：AE4树脂在盐酸溶液中不吸附Al³⁺、Zn²⁺、Mg²⁺；在3 mol/L以上的盐酸溶液中对Fe³⁺吸附性能较好；在7 mol/L以上的盐酸溶液中对Y³⁺的吸附性能较好。含有Y³⁺、Al³⁺、Zn²⁺、Mg²⁺等元素的混合溶液在3 mol/L HCl溶液通过AE4树脂柱后，Fe³⁺基本被全部吸附在树脂柱上；吸附余液调节盐酸浓度至7 mol/L，通过另一根AE4树脂柱，Y³⁺基本被吸附在树脂柱上。最后用0.01 mol/L HCl洗脱吸附在树脂柱上的Y³⁺，得到纯化后的YCl₃溶液。稳定核素和90Y示踪的研究结果表明，采用AE4树脂纯化⁹⁰YCl₃溶液的工艺可行，AE4树脂可用于90YCl3溶液中Fe、Al、Zn、Mg等主要杂质金属元素的去除。

Removal of Metal Impurities from 90YCl3 Solution with Strongly Basic Anion Exchange Resin

The ⁹⁰YCl₃ solution for medical use is generally extracted from the 90Sr/90Y radioactive decay equilibrium system. The ⁹⁰Y solution obtained from ⁹⁰Sr/⁹⁰Y has no carrier, but contains a certain amount of metal impurity. A further purification by using of the concentration of hydrochloric acid is needed before it used for the preparation of ⁹⁰Y radiopharmaceuticals. The adsorption behavior of Y³⁺, Fe³⁺, Al³⁺, Zn²⁺ and Mg²⁺ on AE4 strongly basic anion exchange was studied. AE4 have no adsorbability for Al³⁺, Zn²⁺ and Mg²⁺ in HCl solution. Fe³⁺ was strongly adsorbed by AE4 in hydrochloric acid solution when the concentration above 3 mol/L, and Y³⁺ was also adsorbed by AE4 in hydrochloric acid solution when the concentration above 7 mol/L. By adjusting the concentration of hydrochloric acid in the solution, Y³⁺, Fe³⁺, Al³⁺, Zn²⁺, Mg²⁺ in hydrochloric acid solution can quantitatively passing the solution successively through the first AE4 column where Fe³⁺ is separated and the second AE4 column where Y³⁺ is adsorbed. Finally, a purified YCl₃ solution can be obtained by using 0.01 mol/L HCl elutes. The result of both the stable nuclide and ⁹⁰Y tracer shows that AE4 resin can be used to remove the main impurity metal elements such as Fe, Al, Zn and Mg in ⁹⁰YCl₃ solution.