Application of selective solid-phase extraction using a new core-shell-shell magnetic ion-imprinted polymer for the analysis of ultra-trace mercury in serum of gallstone patients

ABSTRACT

A new ultrasonically assisted spectrophotometric method was developed using stabilized ion polymer on a modified nano-absorbent as a core- shell-shell absorbent (Fe₃O₄@SiO₂@TiO₂–IIP). It has the advantages of further stabilizing the polymer and consequently and much higher efficiency than its conventional adsorbents. The prepared sorbent was characterized and Its parameters were investigated by a Box–Behnken design. The linear dynamic range and limit of detection were 0.20–28.00 µg L^?1 and 0.05 µg L^?1 respectively. In selectivity study, it was founded that imprinting causes increased affinity of the prepared IIP toward Hg²⁺ ion. The proposed IIP is considered to be promising and selective sorbent for solid-phase extraction and preconcentration of Hg²⁺ ion in sera of different types of gallstone patients.