Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson''s disease |
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| Authors: | OM El-Agnaf R Jakes MD Curran A Wallace |
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| Affiliation: | The Murdoch Institute, Royal Children's Hospital, Parkville, Victoria, Australia. fowlerk@cryptic.rch.unimelb.edu.au |
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| Abstract: | Inner centromere protein (INCENP) and centromere protein E (CENPE) are two functionally important proteins of the higher eukaryotic centromere. Using a mouse Incenp genomic DNA and a mouse Cenpe cDNA to analyze recombinant inbred mouse sets, as well as interspecific backcross panels, we have mapped these genes to the proximal regions of mouse Chromosomes 19 and 6, respectively. Comparison of Cenpe and human CENPE, which maps to chromosome region 4q24-->q25, has further identified a new region of homology between the two species. |
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