金属蛋白酶在皮肤构造与老化中所扮的角色(英文)

皮肤细胞间质体 (ECM)是由表皮与真皮产生的各种蛋白构成。破坏ECM的金属蛋白酶(MMP)是引起皮肤老化的重要原因。年龄的增长、环境的影响使皮肤逐渐老化。从分子与细胞层面的角度出发 ,着重分析了ECM与MMP对此所起的根本作用。年龄与紫外线影响会激增MMP2 (MMP的一种 )的活性 ,降低内在TIMP (抑制MMP2的酶 )的作用 ,使胶原蛋白纤维逐渐衰败 ,失去健康的平衡。MMP2激增的活性破坏在表皮与真皮间起支托作用的胶原蛋白 7型 ,可导致皱纹 ;MMP2还破坏胶原蛋白 1型 ,使ECM缺损、萎缩 ,导致微细血管扩张 ,可表现为表面网状血管与黑眼圈现象

The Role for Matrix Metalloproteinases in Skin Construction and Degradation during Aging

:Skin aging involves major changes in the extracellular matrix (ECM) elements of the skin.Most molecules forming the skin ECM are produced by the keratinocytes of the epidermis and the fibroblasts of the dermis.These molecultes in clude collagen,elastin,proteoglycans,fibronectin and other glycoproteins.Deterioration of this supportive matrix plays an important role in the appearance of signs of aging,intrinsic aging as well as actinic aging.The ECM not only acts as a physical support but also has a more biological role since it allows intercellular diffusion of nutrients,metabolites and growth factors.Skin aging is also asociated with a progressive diminution in dermal thickness,collagen content and protein organization.Aging is also respionsible for abnormalities in the stratum corneum of the epidermis where intercellular cohesion is perturbed.Most of these qualities of the skin are essential to a young-looking skin and destructive enzymes such as the collagenases negatively impact the firmness,elasticity and integrity of the ECM.Eventually,these biological phenomenta translate into cosmetic concerns for the aging population.